The monsters in the abyss appear to drop all varieties of runecrafting pouches regardless of your runecrafting level.
Also, it seems you are able to obtain multiple of the same size of pouch. I've only been able to test this with the large pouch so far. I believe I got another drop for the small pouch and the game didn't allow me to pick it up because "you can only have one of each type of pouch". I know I was able to pick up multiple large pouches, but they were all in different trips, so I'm not sure if it was only because I didn't have the pouch in my inventory or not.
I do not yet know if I can actually use multiple large pouches at once since I don't yet have 50 runecrafting, but I'll post an update when that day comes.